Methodology · Version 1.0 — 2026
The Aevum Standard.
Published. Externally audited. Revised annually. The Standard integrates the Blue Zones Power 9, the ACLM Six Pillars, Peter Attia's Five Pillars, the WHO Intrinsic Capacity framework, and the 2024 PMC systematic review of 35 RCTs into a single coherent framework.
Pillar I — Nutrition
HbA1c < 5.3% HOMA-IR < 1.0 hsCRP < 0.5 mg/L ApoB < 60 mg/dL
Mediterranean dietary pattern as default. Caloric moderation calibrated to body composition. Time-restricted eating windowed against circadian biology, not fashion.
Annual Audit Criteria
- Quarterly metabolic panel reviewed by supervising clinician.
- Annual ApoB and Lp(a) for cardiovascular risk stratification.
- Continuous glucose monitoring deployed for 14-day windows, twice yearly.
Pillar II — Movement
VO₂ max > 50 (M) / > 43 (F) at age 50 Grip strength > 40 kg (M) / > 27 kg (F) Resting HR < 60 bpm
Zone 2 cardio as the metabolic foundation. Resistance training across all major movement patterns. VO₂ max treated as the single most predictive biomarker of all-cause mortality.
Annual Audit Criteria
- Annual VO₂ max test (treadmill or cycle ergometer with gas analysis).
- Quarterly DEXA composition scan.
- Movement-pattern screen by certified physical therapist, twice yearly.
Pillar III — Sleep & Stress Regulation
HRV > 50 ms AM Cortisol 10–20 µg/dL Sleep duration > 7 hrs Deep sleep > 1.5 hrs
HRV biofeedback as the daily readout. Cortisol architecture matters more than cortisol level. Deep sleep is the foundation on which the other four pillars are built.
Annual Audit Criteria
- Continuous HRV tracking, monthly review.
- Annual diurnal cortisol four-point test.
- Sleep architecture review (PSG or validated wearable) annually.
Pillar IV — Connection & Purpose
PHQ-9 < 5 UCLA Loneliness Scale < 20 PIL Purpose-in-Life > 100
Moai-style social rings. Volunteering as a structured intervention. Ikigai operationalised as a measurable construct, not a poster.
Annual Audit Criteria
- Quarterly validated psychometric battery.
- Annual social network mapping exercise.
- Purpose alignment review with clinician.
Pillar V — Clinical Oversight & Data
Biological age ≤ chronological age (GrimAge or PhenoAge) Full annual physician review
Physician-reviewed protocols. Annual audit. Integrated data stewardship across wearables, panels, and clinical records.
Annual Audit Criteria
- Annual epigenetic age assessment.
- Comprehensive panel review by supervising physician.
- Data stewardship audit by independent third party.
The Aevum Standard is published, externally audited, and revised annually. Version 1.0 — 2026.